Deadly Wuhan Coronavirus

nivek

As Above So Below
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pigfarmer

tall, thin, irritable
Black Death 700 years ago affects your health now

Black Death 700 years ago affects your health now​


Graves in East London
IMAGE SOURCE,MUSEUM OF LONDON
Image caption,
Human remains from the plague pits in London were used in the genetic analysis.
By James Gallagher
Health and science correspondent

The devastation of the plague pandemic left such an incredible genetic mark on humanity that it's still affecting our health nearly 700 years later.
Up to half of people died when the Black Death swept through Europe in the mid-1300s.
A pioneering study analysing the DNA of centuries-old skeletons found mutations that helped people survive the plague.
But those same mutations are linked to auto-immune diseases afflicting people today.
The Black Death is one of the most significant, deadliest and bleakest moments in human history. It is estimated that up to 200 million people died.
Researchers suspected an event of such enormity must have shaped human evolution. They analysed DNA taken from the teeth of 206 ancient skeletons and were able to precisely date the human remains to before, during or after the Black Death.

The analysis included bones from the East Smithfield plague pits which were used for mass burials in London with more samples coming from Denmark.
Tooth
IMAGE SOURCE,MCMASTER UNIVERSITY
Image caption,
This researcher is analysing an ancient tooth which contains degraded DNA

The standout finding, published in the journal Nature, surrounded mutations in a gene called ERAP2.
If you had the right mutations you were 40% more likely to survive the plague.
"That's huge, it's a huge effect, it's a surprise to find something like that in the human genome," Professor Luis Barreiro, from the University of Chicago, told me.
The gene's job is to make the proteins that chop up invading microbes and show the fragments to the immune system, priming it more effectively to recognise and neutralise the foe.
The gene comes in different versions - those that work well and those that do nothing - and you get a copy from each parent.

So the lucky ones, who were most likely to survive, inherited a high-functioning version from mum and dad.
And the survivors had children and so passed those helpful mutations on so they suddenly became much more common.
"It's huge we see a 10% shift over two to three generations, it's the strongest selection event in humans to date," evolutionary geneticist Professor Hendrik Poinar, from McMaster University, told me.
The results were confirmed in modern day experiments using the plague bacterium - Yersinia pestis. Samples of blood from people with the helpful mutations were more able to resist the infection than those without.
"It's like watching the Black Death unfold in a petri-dish - that's eye-opening," said Prof Poinar.
Tissue analysis
IMAGE SOURCE,UNIVERSITY OF CHICAGO
Even today those plague-resisting mutations are more common than they were before the Black Death.

The problem is they have been linked to auto-immune diseases such as the inflammatory bowel disease Crohn's - what helped keep your ancestors alive 700 years ago but could be damaging your health today.
Other historic forces on our DNA have a legacy we feel. Around 1-4% of modern human DNA comes from our ancestors mating with Neanderthals and this inheritance affects our ability to respond to diseases including Covid.
"So those scars from the past still impact our susceptibility to disease today, in a quite remarkable way," said Prof Barreiro.
Prof Barreiro said the 40% survival advantage was the "strongest selective fitness effect ever estimated in humans". It seemingly dwarfs the benefit of HIV-resistance mutations or those that help digest milk - although he warns direct comparisons are tricky.
The Covid pandemic will not leave a similar legacy though.
Evolution works through your ability to reproduce and pass on your genes. Covid largely kills the elderly who have already passed the point of having children.
It was plague's ability to kill across the age spectrum and in such great numbers that meant it had such a lasting impact.
 

michael59

Celestial

New Boston virus​


Please share this video, this research must STOP. Gain of function research in the USA today using enhanced potential pandemic pathogen (ePPP) research Professor Shmuel Shapira, lead scientist, Israeli Government

https://www.dailymail.co.uk/health/ar

This should be totally forbidden, it's playing with fire Dr Richard Ebright, Rutgers University, New Brunswick The research is a clear example of gain of function research. If we are to avoid a next lab-generated pandemic, it is imperative that oversight of enhanced potential pandemic pathogen research be strengthened. It is imperative that officials at US-government agencies, who repeatedly have placed the public at risk by repeatedly violating the existing policies be held accountable.

Prof David Livermore, microbiology, University of East Anglia given the strong likelihood that the Covid pandemic originated from the escape of a lab-manipulated coronavirus in Wuhan, these experiments seem profoundly unwise Boston University's National Emerging Infectious Diseases Laboratories is one of 13 biosafety level 4 labs in the US Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron 14th October 2022 Boston University School of Medicine

https://www.biorxiv.org/content/10.11

Predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date The Omicron spike (S) protein, unusually large number of mutations, is considered the major driver of these phenotypes We generated chimeric recombinant SARS-CoV-2 A chimera or chimeric virus One virus containing genetic material derived from two or more distinct viruses US Center for Veterinary Biologics;

https://www.aphis.usda.gov/animal_hea

A new hybrid microorganism, created by joining nucleic acid fragments from two or more different microorganisms, in which each of at least two of the fragments, contain essential genes necessary for replication. We generated chimeric recombinant SARS-CoV-2 Encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate, and compared this virus with the naturally circulating Omicron variant. The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor-binding motif, yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells. In K18-hACE2 mice.

https://www.jax.org/strain/034860

K18-hACE2 transgenic mice express human ACE2, including airway epithelia where infections typically begin. Because K18-hACE2 are susceptible to SARS-CoV-2 and SARS-CoV viruses, they are useful for studying antiviral therapies to COVID-19 and SARS. In K18-hACE2 mice Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. This indicates that while the vaccine escape of Omicron is defined by mutations in S, major determinants of viral pathogenicity reside outside of S.

 

wwkirk

Divine
This could have been placed in the politics thread, but it might get lost there.

Some highlights
"David Chokshi, the city’s health commissioner, issued an order in October 2021 requiring all city employees to be inoculated against the virus. Later, Chokshi issued a similar order for private sector employees; Mayor Eric Adams signed a supplementary executive order to that latter mandate carving out exemptions for athletes, musicians, and other performers.

The court deemed both Chokshi and Adams’s orders “arbitrary and capricious,” while also finding that Chokshi’s violated the New York State constitution.

“The Health Commissioner cannot create a new condition of employment for city employees… cannot prohibit an employee from reporting to work… cannot terminate employees. The Mayor cannot exempt certain employees from these orders,” reads the opinion, which was authored by Judge Ralph J. Porzio. Porzio noted that vaccination against Covid-19 does not prevent transmission of the disease, but noted that the decision “is not a commentary on the efficacy of vaccination.”

If it was about safety and public health, no one would be exempt. It is time for the City of New York to do what is right and what is just,” concluded Porzio."
 

nivek

As Above So Below

The COVID symptoms you get depend on how many vaccine jabs you’ve had, major study says

If you’ve ever had COVID, there’s a chance you’re all too familiar with symptoms of the virus, which include a cough, tiredness, and headaches.

But as the virus has evolved and new variants like Delta and Omicron have emerged, its most common symptoms have changed—and now, it seems, which ones you get depends on how many vaccine jabs you’ve had.

Getting vaccinated against COVID reduces your risk of severe illness, hospitalization, and death if you do catch the disease—but according to new research, it could also dictate which batch of the milder, more common symptoms of the virus you end up getting. It’s thought that a large proportion of cases are still asymptomatic.

In an update to the ongoing Zoe Health Study, which has collected data from almost 5 million participants since 2020, researchers said they had identified symptoms that had emerged in recent weeks, noting that they appeared to differ depending on vaccination status.

“Generally, we saw similar symptoms of COVID-19 being reported overall in the app by people who had and hadn’t been vaccinated,” the research team said in its update. “However, fewer symptoms were reported over a shorter period of time by those who had already had a jab, suggesting that they were falling less seriously ill and getting better more quickly.”

Symptoms by vaccination status​


The most common current symptoms reported in those who were fully vaccinated, ranked by prevalence, were…
  1. Sore throat
  2. Runny nose
  3. Blocked nose
  4. Persistent cough
  5. Headache
“Traditional” symptoms from the early months of the pandemic, such as loss of smell, fever, and shortness of breath, ranked way down the list in those who had received two doses of a vaccine, researchers said, being named the sixth, eighth, and 29th most common COVID symptoms.

“Curiously, we noticed that people who had been vaccinated and then tested positive for COVID-19 were more likely to report sneezing as a symptom compared with those without a jab,” they added.

Among those who had only had one vaccine dose, the most common recent symptoms were slightly different:

  1. Headache
  2. Runny nose
  3. Sore throat
  4. Sneezing
  5. Persistent cough
In people who were unvaccinated, the study said, the symptoms were “more recognizable to the traditional original ranking,” though they acknowledged there had been some changes from when COVID first appeared.

If you haven’t had a dose of a COVID vaccine, the symptoms you’re most likely to get with the virus—according to the Zoe study—are…

  1. Headache
  2. Sore throat
  3. Runny nose
  4. Fever
  5. Persistent cough
“Loss of smell comes in at No. 9 and shortness of breath comes far down the list at No. 30, indicating the symptoms as recorded previously are changing with the evolving variants of the virus,” the research team said.

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michael59

Celestial

14 State Attorney General's Object to CDC Child Vaccine Decision​


The Centers for Disease Control and Prevention Advisory Committee on Immunization Practices (ACIP) last week approved adding Covid-19 vaccinations to the recommended vaccine schedules for children and adults. Although the vote for the recommendation was unanimous, several members of the ACIP stressed they were not setting a requirement for anyone to be vaccinated. The recommendation included a statement which stressed this was not a requirement for children to attend school. "Adding the COVID-19 vaccine to the recommended childhood immunization schedule does not constitute a requirement that any child receive the vaccine," offered Dr. Nirav Shah, an ACIP member and Director of Maine's Center for Disease Control and Prevention. The meeting started rumors saying the vote created a nationwide student mandate. Even though this isn’t true, it did start a series of legal moves by state attorney generals.

 

michael59

Celestial

The COVID symptoms you get depend on how many vaccine jabs you’ve had, major study says

If you’ve ever had COVID, there’s a chance you’re all too familiar with symptoms of the virus, which include a cough, tiredness, and headaches.

But as the virus has evolved and new variants like Delta and Omicron have emerged, its most common symptoms have changed—and now, it seems, which ones you get depends on how many vaccine jabs you’ve had.

Getting vaccinated against COVID reduces your risk of severe illness, hospitalization, and death if you do catch the disease—but according to new research, it could also dictate which batch of the milder, more common symptoms of the virus you end up getting. It’s thought that a large proportion of cases are still asymptomatic.

In an update to the ongoing Zoe Health Study, which has collected data from almost 5 million participants since 2020, researchers said they had identified symptoms that had emerged in recent weeks, noting that they appeared to differ depending on vaccination status.

“Generally, we saw similar symptoms of COVID-19 being reported overall in the app by people who had and hadn’t been vaccinated,” the research team said in its update. “However, fewer symptoms were reported over a shorter period of time by those who had already had a jab, suggesting that they were falling less seriously ill and getting better more quickly.”

Symptoms by vaccination status​


The most common current symptoms reported in those who were fully vaccinated, ranked by prevalence, were…
  1. Sore throat
  2. Runny nose
  3. Blocked nose
  4. Persistent cough
  5. Headache
“Traditional” symptoms from the early months of the pandemic, such as loss of smell, fever, and shortness of breath, ranked way down the list in those who had received two doses of a vaccine, researchers said, being named the sixth, eighth, and 29th most common COVID symptoms.

“Curiously, we noticed that people who had been vaccinated and then tested positive for COVID-19 were more likely to report sneezing as a symptom compared with those without a jab,” they added.

Among those who had only had one vaccine dose, the most common recent symptoms were slightly different:

  1. Headache
  2. Runny nose
  3. Sore throat
  4. Sneezing
  5. Persistent cough
In people who were unvaccinated, the study said, the symptoms were “more recognizable to the traditional original ranking,” though they acknowledged there had been some changes from when COVID first appeared.

If you haven’t had a dose of a COVID vaccine, the symptoms you’re most likely to get with the virus—according to the Zoe study—are…

  1. Headache
  2. Sore throat
  3. Runny nose
  4. Fever
  5. Persistent cough
“Loss of smell comes in at No. 9 and shortness of breath comes far down the list at No. 30, indicating the symptoms as recorded previously are changing with the evolving variants of the virus,” the research team said.

.
I haven't been vaccinated. I haven't been sick since the beginning of 2020.
 

nivek

As Above So Below
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nivek

As Above So Below
So the CEO of Moderna who became an absurdly rich billionaire selling the deadly covid vaxx, was also the CEO of the company that helped design and build the Wuhan Lab that covid was released from? And Bill Gates donated to EcoHealth and Wuhan University, and invested in Moderna?

Screenshot_20221111-191526.jpg

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nivek

As Above So Below

Biden's Covid bribe: Americans who get a booster vaccine this winter will get $20 discounts on their groceries

The White House is offering discounts on groceries to Americans who get the new bivalent Covid booster in a desperate bid to boost uptake of the new vaccine.

People who get the Omicron-specific shot at CVS, Safeway, Winn-Dixie, or Rite Aid will get up to $20 off their purchases this winter.

It comes amid a soaring inflation crisis that has driven up the price of household staples. A recent American Farm Bureau report found Thanksgiving dinner this year will cost a whopping 20 per cent more than last year.

The new booster incentive comes ahead of a potential spike in Covid cases and hospitalizations this winter which could put pressure on already-overstretched hospitals.


(More on the link)

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michael59

Celestial

Biden's Covid bribe: Americans who get a booster vaccine this winter will get $20 discounts on their groceries

The White House is offering discounts on groceries to Americans who get the new bivalent Covid booster in a desperate bid to boost uptake of the new vaccine.

People who get the Omicron-specific shot at CVS, Safeway, Winn-Dixie, or Rite Aid will get up to $20 off their purchases this winter.

It comes amid a soaring inflation crisis that has driven up the price of household staples. A recent American Farm Bureau report found Thanksgiving dinner this year will cost a whopping 20 per cent more than last year.

The new booster incentive comes ahead of a potential spike in Covid cases and hospitalizations this winter which could put pressure on already-overstretched hospitals.


(More on the link)

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Alternatively, you could take (adult dosage) Vitamin D3- 4000 units per day and Vitamin K 100 mg per day and stave off most viruses this winter.


 

nivek

As Above So Below

Mask mandate return? HHS report wants to ‘encourage or mandate’ masking to stop long COVID

Masking and social distancing should be encouraged or even mandated once more in public in order to protect people from COVID-19 and from the possibility of suffering from "Long COVID," according to a new report from the Department of Health and Human Services.

The report, commissioned by HHS and produced by research agency Coforma, calls for a broad range of government policies to help people who continue to deal with the lingering effects of COVID. Those policies include an awareness campaign, funding for long COVID support groups, financial support for students and workers, and new health benefits for COVID victims.

Reinstating a mask mandate may be the most controversial recommendation in the report, which says ending that mandate in late 2021 and 2022 is making it harder for people with long COVID.

"The lifting of mask mandates and indifferent attitude toward masking and social distancing typical in many public and private places further isolates people with Long COVID," the report said. As a result, policymakers should "encourage or mandate policies and protocols regarding masking and social distancing in public spaces," it said.

President Biden said in September that the "pandemic is over," but his administration has not let up on the need for funding and policies to keep fighting the virus. Last week, the White House asked Congress for another $10 billion to fight COVID, and a top HHS official said assisting people with long COVID is a long-term priority for the government.


(More on the link)

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nivek

As Above So Below
They've obviously made a mistake with the data on their website, if the screenshot is genuine.

I tried to confirm the screenshot but hit a log-in wall...

...
 
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