Methods to Combat the COVID-19 Coronavirus

Discussion in 'Present & Current Events' started by Thomas R. Morrison, Mar 15, 2020.

  1. nivek

    nivek As Above So Below

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    Here's a ray of hope, a touch of good news...

    ...

    Scientists find new mutation of coronavirus that mirrors a change in the 2003 SARS virus that showed the disease was weakening

    Scientists have discovered a unique mutation to coronavirus in Arizona - and it's a pattern that they've seen before. One of the 382 samples they collected from coronavirus patients in the state was missing a sizeable segment of genetic material.

    In the middle and late stages of the SARS epidemic of 2003, this very same kind of deletion started cropping up in patients around the globe. It's not just any mutation - the change robs the closely related viruses of one of their weapons against the host's immune response, making the infection weaker. As that mutation became widespread, the SARS outbreak wound down. By July - five months after it emerged in Asia in February 23 - there were no new cases, and the outbreak was considered contained.

    Now, the Arizona State University researchers have only found one person who had a version of the virus with this mutation - but they say if genome sequencing for coronavirus become more common, we may find far more.

    Some viruses mutate nearly constantly, making them more difficult for us to keep up with, prevent and treat. HIV is among the most prolific mutators known to man. It replicates itself rapidly as well, making billions of copies of itself in a single day. These traits combined make it exceptionally hard to control and allow the virus to become resistant to drugs.

    From what we know of it so far, the virus causing the current pandemic - SARS-CoV-2 - is far more reliable than something like HIV.

    That's both good and bad.

    On one hand, the less a virus mutates, the better our odds of making a vaccine that can effectively block it are.

    But until we have a vaccine - a wait period for which estimates vary wildly, with some experts saying we could have one by January, others predicting making one will take a year or two, and a few, fringe speculators putting its arrival date a far out as 2036 - the stable coronavirus will continue to reliably infect millions and kill hundreds of thousands.

    (more on the link)

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  2. AD1184

    AD1184 Honorable

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    There is a study from South Korea which indicates that hydroxychloroquine might be an effective post-exposure prophylaxis against Covid-19, after the drug was administered to patients after a mass-exposure event at a Korean hospital due to the presence of a symptomatic and Covid-19 positive healthcare worker.

    Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals? - ScienceDirect

    You might say that the South Korean study mentioned above is not controlled or randomized, and that is why it is not so widely reported. But neither was the US Veterans' Association study which was widely publicized and which had many other flaws. HCQ is hypothesized to inhibit the replication of the virus in the body (this mechanism also requires adequate zinc levels). Dose timing is therefore very important. If you give it to people with advanced Covid-19, as in the VA study, it will be useless. We expect that already, and any studies demonstrating that it has no effect on late-stage Covid-19 are also useless and do not add anything, but of course garner lots of press attention.

    Donald Trump's pushing HCQ has poisoned the well. There are many in the media, and even I think in the scientific and medical establishments, to whom it would be a defeat if the drug that Trump was endorsing turned out to be useful. However, there are indication that it might be. It is also very cheap, in comparison to something like Remdesivir, which costs something like $5,000 per course, and has been given something of a free-ride, despite also having patchy trial results. A course of HCQ is less than 1% of that. Trump should recognize his anti-Midas touch and keep his mouth shut, and people should stop being so petty.
     
    Last edited: May 5, 2020
  3. nivek

    nivek As Above So Below

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    I think the only treatment that is currently effective at curing people with advanced Covid-19 is plasma transfusion...There should be a more concerted effort through sources like the media to encourage people who have overcome Covid-19 on their own to donate plasma for the severe and critical cases...

    ...
     
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  4. AD1184

    AD1184 Honorable

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    Coronavirus: Amount of particles, or 'viral load' affect severity | Daily Mail Online
    This gels with a lot of things I have been reading in other sources about this virus. I don't think it is correct to refer to it as the 'viral load', which is a different concept, but rather the correct term is the inoculum or infective dose. If you live with someone with Covid-19, you may get a worse illness with everything else being equal, because you potentially get a large inoculum by being in close proximity for an extended period. Cases of infection caused by casual momentary contact are probably less worse than those who are exposed to the same person a lot, or to lots of people with the virus, especially to those who are have serious illness (which are conditions that health care workers face). There may be a repeat exposure phenomenon, where lots of small doses also equate to the effect of a large dose.

    Therefore, the danger in getting infected by someone in your household who has Covid-19 is potentially much greater than if you were to get infected at the supermarket, say.
     
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  5. Thomas R. Morrison

    Thomas R. Morrison Administrator

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    I've been scanning the news for early findings from the on-going studies of convalescent plasma therapy, and even now....five months into this outbreak...there are still no results to be found. It's infuriating. I have no idea what could possibly be taking so long - this treatment is being used all around the world and yet nobody has released any assessment data. Wtf?

    And you're absolutely correct - this needs to be a daily news item so people who have recovered can save the lives of those who haven't.

    But this is where the unfathomable incompetence of our government comes in: the only people who qualify to donate blood plasma are those who have treated positive for the virus and then recovered . But thanks to the pitifully sparse availability of testing, only a tiny percentage of recovered patients have been tested for the virus. So most of the people who could be helping out by donating their blood plasma, can't.

    Hopefully somebody somewhere will eventually publish findings about the effectiveness of this therapy so we can put the efficacy question behind us and start promoting a protocol that could save tens of thousands of lives. So far all I can find are very hopeful anecdotal reports about its effectiveness...which are encouraging but next to worthless, from a scientific vantage point.

    I hate to complain without posting a silver lining, so here it is: some researchers are harvesting antibodies from recovered patients, then isolating the different varieties of antibodies and testing their effectiveness against the virus, and then cloning the most potent antibodies, which is known as monoclonal antibody therapy. And a treatment from this process could be available as early as summer's end, they're saying:

    Coronavirus News: New twist on plasma treatment could be ready by summer's end
     
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  6. Thomas R. Morrison

    Thomas R. Morrison Administrator

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    Okay this is my first and possibly only ever Must Read recommendation. Want a simple, scientific understanding of the basic physics of coronavirus epidemiology...so you can quickly and intuitively assess the risks present in any environment? Want to know how many virus particles you have to be exposed to in order to develop an infection, and know how many of those particles are released when somebody breathes, talks, coughs, and sneezes?

    Then read this, and possibly save your own life and many others in the process:

    https://erinbromage.wixsite.com/covid19/post/the-risks-know-them-avoid-them
     
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  7. AlienView

    AlienView Honorable

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    Can Magnetic Fields be used to Combat and even Cure Covid 19 ?

    NOTE: Magnetic therapy dates back to Ancient Egypt and is still popular for things like arthriits.
    People who have studied it have found magnetic field also have anti-bacterial, anti-viral,
    and some say even anti-caneer properties.

    Read this short excerpt:

    "Magnetic Antibiotics:

    There are numerous evidences that microorganisms capable of infecting humans will die in a
    negative magnetic field of a sufficient gauss strength and sufficient duration. This is true whether
    the infectious agent is a virus, bacteria, fungus, parasite or other invading microorganism.

    A man with a culture identification of a tuberculosis lesion on the back of his had, having been
    unsuccessfully treated with various antibiotics, was treated with a plastiform magnet 4” square
    and 1/8” thick with the negative magnetic field facing the lesion and kept on continuously for six
    weeks. This negative magnetic field completely killed the tuberculosis skin lesion. Thus, we
    know there is a magnetic answer for tuberculosis no matter where it is on or in the body.

    A man with viral C hepatitis with a positive fetoprotein test was treated with the negative magnetic
    field of a 4” x 6” x ½” magnet 24 hours a day for several weeks. The viral infection died out and
    the fetoprotein test became zero.
    ...."


    Conclusion from Current Observations

    The death of invading type microorganisms cannot be demonstrated by invitro culture outside of the human body. The death of these invading microorganisms is dependent on invivo infection. The static negative magnetic field strengthens the human cell’s response such that the human cells can kill invading microorganisms. All invading microorganisms of viruses, bacteria, fungi, parasites and others have all responded with death of the microorganism from sufficiently strong static negative magnetic field of sufficient duration. There is no adaptation capacity of these microorganisms to a static negative magnetic field. The good news is that in addition to the life saving value of currently used antibiotics, we now have a static negative magnetic field with universal antibiotic value to which no human invading microorganisms can adapt........"


    See whole article here:
    http://www.lymehub.com/Magnetic_Antibiotics.pdf


    I've been using magnets for years on arthritic joints with much success. On other things, say a bad tooth,
    I found they killed pain but I'v never been able to heal a really bad tooth. Could a strong enough magnetic
    field actually be uses to control and/or kill the Coronavirus???
     
  8. nivek

    nivek As Above So Below

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    Here's a little news on this, glad to see more people are getting involved in donating plasma...

    ....

    New York Orthodox Jews make up HALF of all US plasma donors volunteering blood to help treat COVID-19 patients as the community turns 'tragedy into a superpower'

    New York Orthodox Jews make up half of all US plasma donors volunteering blood to help treat COVID-19 patients, according to a medical expert.

    Dr. Michael Joyner of the Mayo Clinic, who is running a study on the effects of plasma to treat the virus, said more than 5,000 patients across the US have been given plasma treatment so far and, when it comes to donors, 'by far the largest group is our Orthodox friends in New York City. I would be shocked if they were less than half the total,' Joyner told the New York Times.

    Thousands of Americans who have recovered from coronavirus are donating their blood to plasma clinics in the hope that it can be used to treat other people struck down by the virus. And Orthodox Jews are making up a significant proportion of the volunteers as the famously tight-knit community pulls together amid the health crisis and many see their newfound health as a 'blessing', according to medics and community members.

    More than 12,000 New York Orthodox Jews have signed up to various community programs donating blood plasma since April 4 and organizers expect this to reach 30,000 soon, the Times reported. Several grassroots initiatives have sprung up in the local community, with the word spreading via synagogues and community newsletters.


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  9. nivek

    nivek As Above So Below

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    Canadian scientists test whether compounds in marijuana can prevent coronavirus from 'hijacking' human cells

    A team of Canadian scientists is testing whether or not marijuana compounds can block coronavirus infection. Researchers at the University of Lethbridge in Alberta looked at 400 cannabis strains and focused on about a dozen that showed promise in preventing the virus from 'hijacking' our cells.

    They say extracts of cannabidiol (CBD), the main non-psychoactive component of pot - helped lower the number of cell receptors available for coronavirus to attach to by more than 70 percent. However, the team says people should not rush out and by cannabis products and that clinical trials are needed to confirm the results.


    For the study, published in the pre-peer reviewed journal Preprints, the scientists partnered with Pathway Rx, a cannabis therapy research company, and Swysh Inc, a cannabinoid-based research company. The team created artificial 3D human models of oral, airway and intestinal tissues with a sample of high CBD extracts from Cannabis Sativa plants. The extracts were low in THC, the main psychoactive ingredient in marijuana.

    Next, researchers tested the effect the extracts had on angiotensin-converting enzyme 2 (ACE2), the receptors required for the virus to enter human cells. Results showed that the extracts helped reduce the number of receptors that are the 'gateway' for the coronavirus to 'hijack' host cells.

    'A number of them have reduced the number of [virus] receptors by 73 percent, the chance of it getting in is much lower,' lead researchers Dr Igor Kovalchuk, CEO of Pathway Rx, told The Calgary Herald. 'If they can reduce the number of receptors, there's much less chance of getting infected.'

    They also looked at other receptors such as TMPRSS2, which allows the virus to invade cells more easily and multiply quickly. 'Imagine a cell being a large building,' Kovalchuk told CTV News. 'Cannabinoids decrease the number of doors in the building by, say, 70 percent, so it means the level of entry will be restricted. So, therefore, you have more chance to fight it.'

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  10. nivek

    nivek As Above So Below

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    No known animal host and 'almost perfect' human adaption: Top Australian vaccine scientist reveals how COVID-19's unique structure means it's either man-made - or a 'complete fluke' of nature

    Coronavirus is so 'perfectly adapted' to infect humans that the possibility it was made in a Chinese lab can't be ignored, Australian vaccine researchers conclude. Professor Nikolai Petrovsky said the virus was better at attaching itself to human cells than to any other animal, explaining why it has infected five million people.

    The vaccine expert warned the investigation into where COVID-19 started, as proposed by Prime Minister Scott Morrison, was as a result urgently needed and should have begun months ago.

    The startling results of his research were first revealed by the Mail on Sunday on the weekend - and on Wednesday his team gave Daily Mail Australia fresh details about why it must be considered a possibility the virus escaped from a lab in Wuhan.


    [​IMG]
    Coronavirus is so 'perfectly adapted' to infect humans that the possibility it was made in a Chinese lab can't be ignored, vaccine researcher Professor Nikolai Petrovsky concludes.

    The team at Flinders University in Adelaide and Latrobe University in Melbourne studied how well SARS-CoV-2, the virus that causes COVID-19, infected different animals. Coronavirus binds itself to the ACE2 receptor molecule in lung cells using a spike protein - the tighter it can attach itself, the less likely it is to be washed away and the sicker it makes its host.

    Professor Petrovsky expected to find an animal that was most susceptible to this, such as bats, and was likely the original source of the virus - but was shocked when humans came out on top. Furthermore, viruses tend to get better at infecting new species as they adapt over time, but COVID-19 started 'completely optimised from day one without the need to evolve'.

    'This is a new virus that has never been in humans before, but it has an extraordinarily high binding to human receptors, which is very surprising,' he told Daily Mail Australia. 'It is almost perfectly human adapted, it couldn't do any better.

    'We have to ask how that happened. Was it a complete fluke? It can be as nature has many shots at goal and you only see the ones that land.

    'Another possibility which still cannot be excluded is that SARS-CoV-2 was created by a recombination event that occurred inadvertently or consciously in a laboratory handling coronaviruses, with the new virus then accidentally released into the local human population.'

    (more on the link)


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  11. AD1184

    AD1184 Honorable

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    How do a "a cannabinoid-based research company" and a "cannabis therapy research company" make their money? Is it so surprising that organizations devoted to attempting to persuade people that cannabis cures everything claim to have found that it cures Covid-19? Also, the human body likely produces ACE2 for a reason, attempting to remove as much of it as possible from the body may not be good for health.
     
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