Science Says You could Live 500 Years.

Discussion in 'Science, Tech, & Space Exploration' started by Shadowprophet, Jan 9, 2020.

  1. Shadowprophet

    Shadowprophet Truthiness

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    I brought this Up for Discussion As a lot of us ponder our mortality from time to time, To boot this, Longevity is a subject I've always kept up with, Until recently, The longest we could extend our lifespan was to be engineered with the Fox gene and that would only get someone to about 140. This new discovery Extends the natural lifespan by about 500 Percent, By mutating Our Genes, And the news gets even weirder. TO acquire this mutation, You wouldn't even need to be engineered, they can put this in pill form, And More than likely your offspring would inherit it without even needing the pill.

    Here is the Original Article for your leisure.

    Pathways that extend lifespan by 500 percent identified
    Discovery of cellular mechanisms could open door to more effective anti-aging therapies

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    Scientists at the MDI Biological Laboratory, in collaboration with scientists from the Buck Institute for Research on Aging in Novato, Calif., and Nanjing University in China, have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists.

    The research draws on the discovery of two major pathways governing aging in C. elegans, which is a popular model in aging research because it shares many of its genes with humans and because it's short lifespan of only three to four weeks allows scientists to quickly assess the effects of genetic and environmental interventions to extend healthy lifespan. Because these pathways are "conserved," meaning that they have been passed down to humans through evolution, they have been the subject of intensive research. A number of drugs that extend healthy lifespan by altering these pathways are now under development. The discovery of the synergistic effect opens the door to even more effective anti-aging therapies.

    The new research uses a double mutant in which the insulin signaling (IIS) and TOR pathways have been genetically altered. Because alteration of the IIS pathways yields a 100 percent increase in lifespan and alteration of the TOR pathway yields a 30 percent increase, the double mutant would be expected to live 130 percent longer. But instead, its lifespan was amplified by 500 percent. "Despite the discovery in
    C. elegans of cellular pathways that govern aging, it hasn't been clear how these pathways interact," said Hermann Haller, M.D., president of the MDI Biological Laboratory. "By helping to characterize these interactions, our scientists are paving the way for much-needed therapies to increase healthy lifespan for a rapidly aging population."

    The elucidation of the cellular mechanisms controlling the synergistic response is the subject of a recent paper in the online journal Cell Reports entitled "Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity." The authors include Jarod A. Rollins, Ph.D., and Aric N. Rogers, Ph.D., of the MDI Biological Laboratory. "The synergistic extension is really wild," said Rollins, who is the lead author with Jianfeng Lan, Ph.D., of Nanjing University. "The effect isn't one plus one equals two, it's one plus one equals five. Our findings demonstrate that nothing in nature exists in a vacuum; in order to develop the most effective anti-aging treatments we have to look at longevity networks rather than individual pathways."

    The discovery of the synergistic interaction could lead to the use of combination therapies, each affecting a different pathway, to extend healthy human lifespan in the same way that combination therapies are used to treat cancer and HIV, Pankaj Kapahi, Ph.D., of the Buck Institute, has said. Kapahi is a corresponding author of the paper with Rogers and Di Chen, Ph.D., of Nanjing University. The synergistic interaction may also may explain why scientists have been unable to identify a single gene responsible for the ability of some people to live to extraordinary old ages free of major age-related diseases until shortly before their deaths.

    The paper focuses on how longevity is regulated in the mitochondria, which are the organelles in the cell responsible for energy homeostasis. Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysregulation and aging. Rollins' future research will focus on the further elucidation of the role of mitochondria in aging, he said. The research was conducted at the MDI Biological Laboratory and Nanjing University using information from double mutants developed by Kapahi. Rollins' and Rogers' work was supported by the National Institutes of Health (AG056743), the Morris Scientific Discovery Fund and the National Institute of General Medical Sciences (P20GM103423 and P20GM104318).


    For the original Article, And Valid Source, Go here: Pathways that extend lifespan by 500 percent identified: Discovery of cellular mechanisms could open door to more effective anti-aging therapies
     
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  2. Shadowprophet

    Shadowprophet Truthiness

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    Now for my thoughts on this, Well, First of all, that's amazing, But even if possible, it's still impractical, There is no way governments around the world are going to allow the common man to live for five hundred years. Hell, Hospitals have been letting elderly people die that could have been saved for endless decades, Stating that "It was just there time to go"

    The Sad truth is, Genetics and life span don't always get to determine someone's age of Death, Sometimes, It's just a nihilistic health caregiver that thinks you have lived long enough.

    It's Sad But True, Imagine how overpopulation would be an issue if people lived that long, Sadly, No, I think only the rich and powerful will have access to life spans like this. What are your thoughts on this Guys?
     
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  3. Ron67

    Ron67 Ignorance isn’t bliss!

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    I believe that in the not too distant future there will be a manipulated war or pandemic to thin the herd.The elites don’t need our slave labour as much as they used to as artificial intelligence and robotics replace humans in the work force.As resources dwindle and the population rises we will be surplus to requirements.
     
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  4. ChrisIB

    ChrisIB Honorable

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    There seems to be a syncronicity about these things so perhaps FTL will arrive at the same time robots make jobs a non requirement, and there will not be a need.
    If they did do it, modern medicine's responsive so it will need to be quick. And they would need to hobble the CDC. Given the ageing population, the old would be a prime target.
     
    Last edited: Jan 10, 2020
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  5. Ron67

    Ron67 Ignorance isn’t bliss!

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    Yep the elderly would definitely be an easy target,I would imagine a flu could be altered that proved fatal to the elderly and vulnerable.The CDC would be powerless.
     
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  6. ChrisIB

    ChrisIB Honorable

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    The ageing population is a huge problem in China due to the previous one child policy.
     
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